The Three Core Paradigms of Drug Delivery
Martech Outlook | Friday, January 28, 2022
Drug delivery challenges have resulted in the development of drug delivery techniques and commercial products.
Fremont, CA: Many pharmaceutical treatments have been developed due to drug delivery methods, which improve patient health by improving therapeutic delivery to the target location, decreasing off-target accumulation, and increasing patient compliance. Drug delivery technology evolved to solve the issues that arose as therapeutic modalities extended beyond small molecules to encompass nucleic acids, peptides, proteins, and antibodies.
Paradigms of drug delivery:
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Drug modifications
A drug's modification includes chemical changes to its structure and conjugation to recognized moieties or targeted ligands. The goal is to modify interactions between the drug and molecules, cells, and tissues in the body and interactions between the drug and its target location. Drug changes have been used to improve the delivery of all therapeutic classes. Drug changes have evolved to accommodate the evolving structural complexity, specificity, and function of each therapeutic class and are currently being utilized and developed for cell treatments.
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Modifications in microenvironment
Environment modifications cover a wide range of techniques, from highly targeted changes at the site of action to systemically injected adjuvants that affect the host environment. Environmental alterations, taken as a whole, provide a wide medication delivery method that can aid in the navigation of biological obstacles. Modulators of the microenvironment can also be employed to affect physiological fluids or mechanical processes that prevent drugs from working.
Drug delivery systems
Modifications to the drug and its surroundings can adjust and maximize the drug's activity. By constructing an interface between the drug and its milieu, drug delivery systems can combine these two methodologies. The early years of modern drug delivery discovered that changing a drug's rate of release in the body can change its PK parameters, specifically its biodistribution, half-life, total drug exposure over time, and maximum concentration in serum175. Although adjusting the dose, frequency of administration, and infusion rates can all have an effect on these parameters, the emergence of controlled-release delivery systems allowed for a better level of control.
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